Karyopharm Therapeutics Inc risk profile
42 Elevated one input has moved against it
Measured 21 October 2026 from KPTI's filed statements. Recomputed nightly.
42 (Elevated), driven by Leverage and coverage at 94, over 6 weighted categories on the MANUFACTURER profile.
What is measured
| Mechanism | Reading | Band | Direction | Driver |
|---|---|---|---|---|
| Market expectation | 80 | Acute | Volatile | One-year price volatility — 126.1% |
| Operating pressure | 1 | Contained | Easing | Costs outgrowing revenue — -11.1 percentage points |
| Cash conversion | 57 | Elevated | Easing | Free-cash-flow margin — -51.6% |
| Leverage and coverage | 94 | Acute | Worsening | Net debt to EBITDA |
| Competitive position | 30 | Normal | Stable | Revenue-growth gap against peers — -13.9 percentage points |
| Concentration | 49 | Elevated | Stable | Customer concentration — 2,050 HHI |
These are descriptive readings of disclosed mechanisms, not investment advice, and not a prediction. A band says where a measured input sits, never what to do about it or what happens next.
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Financials, valuation and price history for Karyopharm Therapeutics Inc